1-Methyl-4-(methylamino)piperidine → HCID 67000733, compound

HRID 562072Notes

Reaction equation

HRID 562072 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([S:10]([N:13]1[CH2:18][CH2:17][CH:16]([C:19]2[C:27]3[C:22](=[C:23]([C:43]([NH2:45])=[O:44])[CH:24]=[C:25]([C:28]4[CH:32]=[C:31]([CH2:33][N:34]([CH3:42])[CH:35]5CC[N:38](C)[CH2:37][CH2:36]5)[S:30][CH:29]=4)[CH:26]=3)[NH:21][CH:20]=2)[CH2:15][CH2:14]1)(=[O:12])=[O:11])[CH3:9].CNC1CCN(C)CC1>>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:37]([CH2:36][CH2:35][N:34]([CH2:33][C:31]1[S:30][CH:29]=[C:28]([C:25]2[CH:26]=[C:27]3[C:22](=[C:23]([C:43]([NH2:45])=[O:44])[CH:24]=2)[NH:21][CH:20]=[C:19]3[CH:16]2[CH2:17][CH2:18][N:13]([S:10]([CH2:8][CH3:9])(=[O:11])=[O:12])[CH2:14][CH2:15]2)[CH:32]=1)[CH3:42])#[N:38]

Participants

3

Reactant 2

HCID 5663231-Methyl-4-(methylamino)piperidineHCID 66722800HCID 66722800, compound

Product 1

HCID 67000733HCID 67000733, compoundYield 42.5%

Procedure

The title compound was prepared according to the general procedure for 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-(5-{[methyl(1-methyl-4-piperidinyl)amino]methyl}-3-thienyl)-1H-indole-7-carboxamide trifluoroacetate, substituting 3-(methylamino)propanenitrile (84.12 mg, 1.0 mmol) for N,1-dimethyl-4-piperidinamine to afford 24 mg of the title compound (42.5%).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-808208bde3b349b5811785b3ab58bd2a
Source dataset
uspto-grants-2011_11
Patent number
US08063071B2

Reaction notes

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