反应详情

To a solution of 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[3-formyl-4,5-bis(methyloxy)phenyl]-1H-indole-7-carboxamide (30 mg, 0.06 mmol) in methanol (2 mL), zinc chloride (5 mg, 0.03 mmol), sodium cyanoborohydride (5 mg, 0.06 mmol) and dimethylamine (100 μL, 0.30 mmol). The mixture was stirred at room temperature for 2 h then reacted in the microwave at 100° C. for 30 min. The resulting mixture was purified by Gilson Preparatory HPLC to give 11 mg of the title compound (34.7%).

1. customthen reacted in the microwave at 100° C. for 30 min
2. customThe resulting mixture was purified by Gilson Preparatory HPLC