Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 56234생성일: 2026년 10월 25일
4-Morpholino-3-(trifluoromethyl)aniline → N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide
https://huagongshe.com/reaction/56234
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Morpholino-3-(trifluoromethyl)aniline | HCID 2771329 | — |
| 반응물 | But-1-ene-1,3-dione | HCID 12642904 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide | HCID 117966079 | 75% |
반응 단계
A mixture of 3-trifluoromethyl-4-morpholinoaniline (4.0 g, 16.2 mmol), EtOAc (30 mL) and acetyl ketene (2.73 g, 32.5 mmol) was stirred at 90° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a yellow solid (4.0 g, 75%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09434695B2 |
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| 출처 데이터셋 | uspto-grants-2016_09 |
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| ORD ID | ord-8882f056f76f4dc1830b0d8993567b22 |
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| 출처 메모 | uspto-grants-2016_09 |
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