反应详情

温度

90 °C

A mixture of 3-trifluoromethyl-4-morpholinoaniline (4.0 g, 16.2 mmol), EtOAc (30 mL) and acetyl ketene (2.73 g, 32.5 mmol) was stirred at 90° C. overnight. The mixture was cooled to rt and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1) to give the title compound as a yellow solid (4.0 g, 75%).

1. temperatureThe mixture was cooled to rt
2. concentrationconcentrated in vacuo
3. customThe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=1:1)