Ammonia → (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide

HRID 56235Notes

Reaction equation

HRID 56235 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([NH:15][C:16](=[O:21])[CH2:17][C:18](=O)[CH3:19])[CH:6]=[CH:7][C:8]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[NH3:24]>CO>[NH2:24]/[C:18](/[CH3:19])=[CH:17]\[C:16]([NH:15][C:5]1[CH:6]=[CH:7][C:8]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)=[C:3]([C:2]([F:23])([F:22])[F:1])[CH:4]=1)=[O:21]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 117966079N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide

Product 1

HCID 90024162(Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide (4.0 g, 12.1 mmol), MeOH (20 mL) and ammonia (20 mL) was stirred at rt overnight. The mixture was then concentrated in vacuo to give the title compound, which was used for next step without further purification.

Workup

  1. concentrationThe mixture was then concentrated in vacuo

Sources & evidence

ORD record
ord-ec3e13da603d435db0061cc3f8e97f5a
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Reaction notes

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