化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide | HCID 117966079 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (Z)-3-amino-N-(3-trifluoromethyl-4-morpholinophenyl)but-2-enamide | HCID 90024162 | — |
反応手順
A mixture of N-(3-trifluoromethyl-4-morpholinophenyl)-3-oxobutanamide (4.0 g, 12.1 mmol), MeOH (20 mL) and ammonia (20 mL) was stirred at rt overnight. The mixture was then concentrated in vacuo to give the title compound, which was used for next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434695B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-ec3e13da603d435db0061cc3f8e97f5a |
| 出典メモ | uspto-grants-2016_09 |