Ammonia → HCID 90030960, compound

HRID 56240Notes

Reaction equation

HRID 56240 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([CH:24]=[CH:25][CH:26]=1)[O:6][CH2:7][N:8]1[C:16]2[C:11](=[CH:12][CH:13]=[C:14]([NH:17][C:18](=[O:23])[CH2:19][C:20](=O)[CH3:21])[CH:15]=2)[CH:10]=[CH:9]1)#[N:2].[NH3:27]>CO>[NH2:27]/[C:20](/[CH3:21])=[CH:19]\[C:18]([NH:17][C:14]1[CH:15]=[C:16]2[C:11]([CH:10]=[CH:9][N:8]2[CH2:7][O:6][C:5]2[CH:24]=[CH:25][CH:26]=[C:3]([C:1]#[N:2])[CH:4]=2)=[CH:12][CH:13]=1)=[O:23]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 90031188HCID 90031188, compound

Product 1

HCID 90030960HCID 90030960, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of N-(1-((3-cyanophenoxy)methyl)-1H-indol-6-yl)-3-oxobutanamide (1.04 g, 2.99 mmol), MeOH (20 mL) and ammonia (20 mL) was stirred at rt overnight. The mixture was concentrated in vacuo to give the title compound, which was used for next step without further purification.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-e727c143835b4fac9db5b24131a6215e
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Reaction notes

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