Bromotrimethylsilane → HCID 66832668, compound

HRID 562407Notes

Reaction equation

HRID 562407 reaction equation
Br[Si:2]([CH3:5])([CH3:4])[CH3:3].C([O:9][P:10]([CH2:16][CH:17]1[CH2:19][CH2:18]1)(=[O:15])[O:11]C(C)C)(C)C>>[CH3:3][Si:2]([O:9][P:10]([CH2:16][CH:17]1[CH2:19][CH2:18]1)(=[O:15])[O:11][Si:2]([CH3:5])([CH3:4])[CH3:3])([CH3:5])[CH3:4]

Participants

3

Reactant 2

HCID 76113BromotrimethylsilaneHCID 86618280HCID 86618280, compound

Product 1

HCID 66832668HCID 66832668, compound

Conditions

Temperature
5 °C

Procedure

Bromotrimethylsilane (43 mL, 0.326 mol) was added dropwise to cyclopropylmethyl-phosphonic acid diisopropyl ester (18.00 g, 81.8 mmol) stirred in a reaction flask chilled to 5° C. The resulting solution was allowed to warm to ambient temperature, stirred for three hours, and then concentrated by rotary evaporation yielding crude cyclopropylmethyl-phosphonic acid bis(trimethylsilyl) ester which was used without further purification.

Workup

  1. temperatureto warm to ambient temperature
  2. stirringstirred for three hours
  3. concentrationconcentrated by rotary evaporation

Sources & evidence

ORD record
ord-2ccaeb84dec146f2ab077bd6e903d1dd
Source dataset
uspto-grants-2011_11
Patent number
US08067395B2

Reaction notes

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