HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(3-Aminopropyl)morpholine → 6-Amino-2-butoxy-9-[3-(3-morpholin-4-yl-propylamino)-propyl]-7,9-dihydro-purin-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(3-Aminopropyl)morpholine | HCID 61055 | — |
| Reactant | 2-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine | HCID 59288031 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-Amino-2-butoxy-9-[3-(3-morpholin-4-yl-propylamino)-propyl]-7,9-dihydro-purin-8-one | HCID 66962280 | — |
Reaction Steps
The product of step (vii) (4 g) was suspended in acetonitrile (40 ml) and 4-(3-aminopropyl)morpholine (15 ml) was added. The mixture was stirred under reflux for 14 h. then the mixture evaporated under reduced pressure. The residue was purified by RPHPLC. Yield 3.59 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067411B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0b4ed594503f4d18a56630a937f3f9d3 |
| Source note | uspto-grants-2011_11 |