N-(3-Aminopropyl)morpholine → 6-Amino-2-butoxy-9-[3-(3-morpholin-4-yl-propylamino)-propyl]-7,9-dihydro-purin-8-one

HRID 562489Notes

Reaction equation

HRID 562489 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:20])[N:6]2[CH2:16][CH2:17][CH2:18]Br.[NH2:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1>C(#N)C>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:20])[N:6]2[CH2:16][CH2:17][CH2:18][NH:21][CH2:22][CH2:23][CH2:24][N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1

Participants

4

Reactant 2

HCID 61055N-(3-Aminopropyl)morpholineHCID 592880312-Butoxy-9-(3-bromopropyl)-7,8-dihydro-8-oxoadenine

Product 1

HCID 669622806-Amino-2-butoxy-9-[3-(3-morpholin-4-yl-propylamino)-propyl]-7,9-dihydro-purin-8-one

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The product of step (vii) (4 g) was suspended in acetonitrile (40 ml) and 4-(3-aminopropyl)morpholine (15 ml) was added. The mixture was stirred under reflux for 14 h. then the mixture evaporated under reduced pressure. The residue was purified by RPHPLC. Yield 3.59 g.

Workup

  1. temperatureunder reflux for 14 h.
  2. customthe mixture evaporated under reduced pressure
  3. customThe residue was purified by RPHPLC

Sources & evidence

ORD record
ord-0b4ed594503f4d18a56630a937f3f9d3
Source dataset
uspto-grants-2011_11
Patent number
US08067411B2

Reaction notes

Loading…