反应详情

温度

65 °C

Sodium (3.7 g) was added to absolute MeOH (400 ml) under a nitrogen atmosphere. To this solution was added the product from step (iii) (28.5 g) and the mixture was stirred at 65° C. for 9 h. The mixture was concentrated in vacuo and 500 ml of water added. The aqueous phase was extracted with ethyl acetate, washed with brine and dried. The subtitle compound was obtained after crystallisation from diethyl ether. Yield 14.2 g.

1. concentrationThe mixture was concentrated in vacuo and 500 ml of water
2. additionadded
3. extractionThe aqueous phase was extracted with ethyl acetate
4. washwashed with brine
5. customdried