HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 6-Amino-9-(3-chloropropyl)-2-butoxy-7,9-dihydro-8H-purin-8-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 9-(3-Chloropropyl)-2-butoxy-8-methoxy-9H-purin-6-amine | HCID 59252637 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-Amino-9-(3-chloropropyl)-2-butoxy-7,9-dihydro-8H-purin-8-one | HCID 67464941 | — |
Reaction Steps
The product of step (vi) (29.8 g) was dissolved in MeOH (60 ml) and treated with 4M hydrogen chloride in dioxane (60 ml). The mixture was stirred at rt for 2 hours, cooled to 0° C. and neutralised with 3.5% aqueous ammonia solution. The solid was filtered off, washed with water then MeOH and dried Yield 27.2 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067413B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-7c3d67d92af04ac0ab9264987ea2b8b6 |
| Source note | uspto-grants-2011_11 |