HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562501Generated: October 30, 2026
Potassium Carbonate → 1-[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]pyrrolidine-2,5-dione
https://huagongshe.com/reaction/562501
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Succinimide | HCID 11439 | — |
| Reactant | 6-Amino-9-(3-chloropropyl)-2-butoxy-7,9-dihydro-8H-purin-8-one | HCID 67464941 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 1-[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]pyrrolidine-2,5-dione | HCID 25072080 | 35.8% |
Reaction Steps
The product from example 1 step (vii) (0.15 g) was dissolved in DMSO (2 mL) and succinimide (0.25 g) and potassium carbonate (0.07 g) was added. The reaction mixture stirred at 60° C. for 16 h. The reaction mixture was filtered through a filter disc and purified via RP-prep-HPLC to give title the compound (0.065 g)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08067413B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-d59d957e72e44085920fd50680b5be88 |
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| Source note | uspto-grants-2011_11 |
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