Potassium Carbonate → 1-[3-(6-Amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)propyl]pyrrolidine-2,5-dione

HRID 562501Notes

Reaction equation

[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:20])[N:6]2[CH2:16][CH2:17][CH2:18]Cl.[C:21]1(=[O:27])[NH:25][C:24](=[O:26])[CH2:23][CH2:22]1.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:20])[N:6]2[CH2:16][CH2:17][CH2:18][N:25]1[C:21](=[O:27])[CH2:22][CH2:23][C:24]1=[O:26]

Participants

Conditions

Temperature: 60 °C

Procedure

The product from example 1 step (vii) (0.15 g) was dissolved in DMSO (2 mL) and succinimide (0.25 g) and potassium carbonate (0.07 g) was added. The reaction mixture stirred at 60° C. for 16 h. The reaction mixture was filtered through a filter disc and purified via RP-prep-HPLC to give title the compound (0.065 g)

Workup

filtrationThe reaction mixture was filtered through a filter disc
custompurified via RP-prep-HPLC

Sources & evidence

ORD record: ord-d59d957e72e44085920fd50680b5be88
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08067413B2

Reaction notes

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