反应详情

Imatinib base (3 g) was suspended in ethanol (60 ml, 96%) at −10° C. Methanesulfonic acid (0.375 ml) was added with stirring and the suspension was stirred for additional 20 min at −5° C. obtaining thus the solution of imatinib mesylate. Than the solution was allowed to crystallize without stirring at −5° C. for 3 hours. t-Butyl methyl ether (50 ml) was added, the white solid was filtered, washed with petrolether (50 ml) and dried in a stream of nitrogen for 1 h to obtain imatinib mesylate Form IV (3.18 g, yield: 89%).

1. stirringthe suspension was stirred for additional 20 min at −5° C.