反应详情

To a suspension of 2-t-butoxycarbonylamino-2-methylpropane-1,3-diol (20.0 g, 97.4 mmol) in isopropyl ether (200 ml) were added successively vinyl hexanoate (16.3 ml, 0.10 mol) and lipase [Immobilized lipase from Pseudomonas sp., TOYOBO, 0.67 U/mg] (0.8 g) with stirring, and the resulting mixture was stirred at room temperature for 2 hours. After stirring, the reaction mixture was filtered and evaporated in vacuo. The residue obtained was purified by chromatography on a silica gel column using a mixed solvent of hexane and ethyl acetate (10:1-2:1) as the eluent to afford the title compound (25.0 g, yield: 85%).

1. stirringthe resulting mixture was stirred at room temperature for 2 hours
2. stirringAfter stirring
3. filtrationthe reaction mixture was filtered
4. customevaporated in vacuo
5. customThe residue obtained
6. customwas purified by chromatography on a silica gel column