反应详情

A 200 mg (1.0 mmol) of 5-chlorothiophenesulfonamide was slurried in 0.5 mL of oxalyl chloride and refluxed for 6 h. The solvent was removed in vacuo and 36 mg of the resulting solid was dissolved in 240 μl, acetonitrile and treated with 40 mg (0.14 mmol) 2-(4-amino-2-methylphenyl)-5-chlorobenzo[c]azoline-1,3-dione. After stirring for 1 h, the solvent was removed and the residue was purified by RP-HPLC to give 33 mg (44%) of the titled compound. ES-MS (M+H)+=538(2Cl).

1. temperaturerefluxed for 6 h
2. customThe solvent was removed in vacuo and 36 mg of the resulting solid
3. dissolutionwas dissolved in 240 μl, acetonitrile
4. customthe solvent was removed
5. customthe residue was purified by RP-HPLC