Ammonium Hydroxide → HCID 60787139, compound

HRID 56267Notes

Reaction equation

HRID 56267 reaction equation
[NH4+:1].[OH-].[CH:3]1([O:9][CH2:10][C:11](Cl)=[O:12])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1>C(Cl)Cl>[CH:3]1([O:9][CH2:10][C:11]([NH2:1])=[O:12])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 124841232-(Cyclohexyloxy)acetyl chloride

Product 1

HCID 60787139HCID 60787139, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 15 mL of NH4OH (25-28%) was added a solution of 2-(cyclohexyloxy)acetyl chloride (1.01 g, 5.72 mmol) in DCM (2 mL) in an ice bath and the mixture was stirred at rt for 5 min and extracted with DCM (20 mL×3). The combined organic layers were washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (0.5 g, 56%).

Workup

  1. extractionextracted with DCM (20 mL×3)
  2. washThe combined organic layers were washed with brine (20 mL×2)
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4c29a6eefae0405481d333a91e564b39
Source dataset
uspto-grants-2016_09
Patent number
US09434695B2

Reaction notes

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