反应详情

温度

40 °C

To a solution of KOH (2.38 g, 42.4 mmol) in mixed solvents of water (50 mL) and ethanol (70 mL) was added ethyl-2-(3-fluorophenoxy)-2-methylpropanoate (3.20 g, 14.1 mmol) in one portion and the mixture was stirred at 40° C. for 2 h. The mixture was cooled to 0° C., acidified to pH 3 with concentrated hydrochloric acid and extracted with DCM (20 mL×2). The combined organic layers were washed with brine (20 mL×2), dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as a white solid (1.70 g, 61%).

1. temperatureThe mixture was cooled to 0° C.
2. extractionextracted with DCM (20 mL×2)
3. washThe combined organic layers were washed with brine (20 mL×2)
4. dry with materialdried over anhydrous Na2SO4
5. concentrationconcentrated in vacuo