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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 562891Generated: October 27, 2026

Sodium hydride → 3-Fluoro-2-hydroxybenzonitrile

https://huagongshe.com/reaction/562891

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant2-(Methylsulfonyl)ethanolHCID 84834—
Reactant2,3-DifluorobenzonitrileHCID 88935—
SolventDimethylformamideHCID 6228—
Product3-Fluoro-2-hydroxybenzonitrileHCID 50998841—

Reaction Steps

Sodium hydride was added to a DMF solution of 2,3-difluorobenzonitrile and 2-(methylsulfonyl)ethanol, followed by stirring at room temperature to obtain 3-fluoro-2-hydroxybenzonitrile. FN: 136.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08067446B2
Source datasetuspto-grants-2011_11
ORD IDord-19370ef47ff243278ad447ff84ba13c4
Source noteuspto-grants-2011_11