Sodium hydride → 3-Fluoro-2-hydroxybenzonitrile
Reaction equation
[H-].[Na+].F[C:4]1[C:11]([F:12])=[CH:10][CH:9]=[CH:8][C:5]=1[C:6]#[N:7].CS(CCO)(=O)=[O:15]>CN(C=O)C>[F:12][C:11]1[C:4]([OH:15])=[C:5]([CH:8]=[CH:9][CH:10]=1)[C:6]#[N:7]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium hydride was added to a DMF solution of 2,3-difluorobenzonitrile and 2-(methylsulfonyl)ethanol, followed by stirring at room temperature to obtain 3-fluoro-2-hydroxybenzonitrile. FN: 136.
Sources & evidence
- ORD record
- ord-19370ef47ff243278ad447ff84ba13c4
- Source dataset
- uspto-grants-2011_11
- Patent number
- US08067446B2
Reaction notes
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