N-bromobutanimide → 5-Bromo-3-fluoro-2-hydroxybenzonitrile

HRID 562892Notes

Reaction equation

HRID 562892 reaction equation
[F:1][C:2]1[C:3]([OH:10])=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[Br:11]N1C(=O)CCC1=O>C(#N)C>[Br:11][C:8]1[CH:9]=[C:2]([F:1])[C:3]([OH:10])=[C:4]([CH:7]=1)[C:5]#[N:6]

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 509988413-Fluoro-2-hydroxybenzonitrile

Product 1

HCID 580769375-Bromo-3-fluoro-2-hydroxybenzonitrile

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3-Fluoro-2-hydroxybenzonitrile and N-bromosuccinimide were stirred at room temperature in acetonitrile to obtain 5-bromo-3-fluoro-2-hydroxybenzonitrile. EI: 215, 217.

Sources & evidence

ORD record
ord-29fc5b8a6ddf45a780c965c9286c415e
Source dataset
uspto-grants-2011_11
Patent number
US08067446B2

Reaction notes

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