Ammonia → 2,2-Difluoro-2-(3-fluorophenoxy)acetamide
Reaction equation
[F:1][C:2]([F:16])([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)[C:3](OCC)=[O:4].[NH3:17]>CO>[F:1][C:2]([F:16])([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([F:15])[CH:10]=1)[C:3]([NH2:17])=[O:4]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate (3.5 g, 14.9 mmol), MeOH (10 mL) and ammonia (5.09 g) in a 20 mL of sealing tube was stirred at 100° C. for 24 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.
Workup
- temperatureThe mixture was cooled to rt
- concentrationconcentrated in vacuo
Sources & evidence
- ORD record
- ord-157b05bda72b46399b46322f13efa189
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09434695B2
Reaction notes
Loading…