HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2,2-Difluoro-2-(3-fluorophenoxy)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate | HCID 66455005 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,2-Difluoro-2-(3-fluorophenoxy)acetamide | HCID 90022910 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of ethyl 2,2-difluoro-2-(3-fluorophenoxy)acetate (3.5 g, 14.9 mmol), MeOH (10 mL) and ammonia (5.09 g) in a 20 mL of sealing tube was stirred at 100° C. for 24 h. The mixture was cooled to rt and concentrated in vacuo to give the title compound, which was used for next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09434695B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-157b05bda72b46399b46322f13efa189 |
| Source note | uspto-grants-2016_09 |