反应详情

A mixture of 4-(2,6-difluoro-4-nitrophenyl)morpholine (4.71 g, 19.3 mmol), THF (30 mL), ethanol (30 mL) and Pd/C (2.0 g, 10%) was stirred at rt under H2 overnight. The mixture was filtered and concentrated in vacuo and the residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=8:1) to give the title compound as a yellow solid (3.62 g, 88%).

1. filtrationThe mixture was filtered
2. concentrationconcentrated in vacuo
3. customthe residue was purified by a silica gel column chromatography (PE/EtOAc (V/V)=8:1)