2-Aminothiazole → HCID 59252755, compound

HRID 563371Notes

Reaction equation

HRID 563371 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]4[CH2:19][CH:18]4[C:20](O)=[O:21])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[NH2:23][C:24]1[S:25][CH:26]=[CH:27][N:28]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]4[CH2:19][CH:18]4[C:20]([NH:23][C:24]4[S:25][CH:26]=[CH:27][N:28]=4)=[O:21])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 67005926HCID 67005926, compound

Product 1

HCID 59252755HCID 59252755, compoundYield 7%

Procedure

Example 103 was prepared from 2-(1-(4-fluorophenyl)-1H-indazol-5-yl)cyclopropanecarboxylic acid (34 mg, 0.115 mmol) and 2-aminothiazole using General Coupling Method B to give 3 mg (7% yield). MS found: (M+H)+=379.

Workup

  1. customto give 3 mg (7% yield)

Sources & evidence

ORD record
ord-a9f30ff4d60847bda04269aa7e675e7b
Source dataset
uspto-grants-2011_11
Patent number
US08067447B2

Reaction notes

Loading…