反应详情

Methyl 1-(4-fluorophenyl)-6-isopropyl-1H-indazole-5-carboxylate (175 mg, 0.56 mmol) was dissolved in 5 mL THF and 1M LiBH4 in THF (3 mmol) was added. Heated at reflux. After 12 h, the reaction was quenched with MeOH, poured into brine and extracted with EtOAc×3. The organic layers were dried over MgSO4, filtered, and concentrated. The residue was purified on SiO2 by MPLC using 1:3 EtOAc/hexane. Obtained 148 mg (93% yield) of (1-(4-fluorophenyl)-6-isopropyl-1H-indazol-5-yl)methanol. MS found: (M+H)+=285.

1. temperatureHeated
2. temperatureat reflux
3. customthe reaction was quenched with MeOH
4. additionpoured into brine
5. extractionextracted with EtOAc×3
6. dry with materialThe organic layers were dried over MgSO4
7. filtrationfiltered
8. concentrationconcentrated
9. customThe residue was purified on SiO2 by MPLC