反应详情

Methyl 3-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-2,2-dimethylpropanoate (121 mg, 0.355 mmol) was heated to 100 C overnight in a mixture of 2 M NaOH/MeOH/DMSO (1:1:1). The next day, the reaction was cooled, acidified to pH 5 with HCl and extracted 2×EtOAc. The organic layers were washed with water×2, dried over MgSO4, filtered, and concentrated in vacuo to give 90 mg (80% yield) of acid 3-(1-(4-fluorophenyl)-6-methyl-1H-indazol-5-yl)-2,2-dimethylpropanoic acid. MS found: (M+H)+=327.

1. temperatureThe next day, the reaction was cooled
2. extractionextracted 2×EtOAc
3. washThe organic layers were washed with water×2
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo