反应详情

温度

110 °C

A mixture of methyl 2,2-dimethyl-3-phenyl-3-(3-phenyl-1H-indazol-6-yl)propanoate (45 mg, 0.12 mmol), lithium hydroxide monohydrate (50 mg, 1.2 mmol), water (2 mL), and dioxane (4 mL) was stirred at 110° C. overnight. The mixture was cooled to rt and partitioned between water (5 mL) and diethyl ether (10 mL). The ether layer was extracted with water (10 mL). The combined aqueous solutions were acidified with 6N hydrochloric acid, extracted with ethyl acetate (15 mL), washed with brine (10 mL), dried (Na2SO4) and concentrated to give 2,2-dimethyl-3-phenyl-3-(3-phenyl-1H-indazol-6-yl)propanoic acid (46 mg, 0.12 mmol, 100% yield) as a glassy solid.

1. temperatureThe mixture was cooled to rt
2. custompartitioned between water (5 mL) and diethyl ether (10 mL)
3. extractionThe ether layer was extracted with water (10 mL)
4. extractionextracted with ethyl acetate (15 mL)
5. washwashed with brine (10 mL)
6. dry with materialdried (Na2SO4)
7. concentrationconcentrated