反应详情

Methyl 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropanoate (700 mg, 1.87 mmol) was dissolved in 45 mL MeOH/H2O (8:1) and treated with NaOH (2 M, 10.8 mmol, 5.4 mL). The reaction was complete in 2 hours and was acidified with 1 M HCl and extracted 3×EtOAc, the combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo to give pure 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropanoic acid (620 mg, 92%) as a clear oil. MS found: (M+H)+=361

1. extractionextracted 3×EtOAc
2. dry with materialthe combined organic layers were dried over MgSO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo