1-Methyl-1H-1,2,4-triazol-3-amine → 3-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-N-(1-methyl-1H-1,2,4-triazol-3-yl)-3-phenylpropanamide

HRID 563406Notes

Reaction equation

HRID 563406 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:18][C:19]([OH:21])=O)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[CH3:28][N:29]1[CH:33]=[N:32][C:31]([NH2:34])=[N:30]1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH2:18][C:19]([NH:34][C:31]4[N:32]=[CH:33][N:29]([CH3:28])[N:30]=4)=[O:21])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5665031-Methyl-1H-1,2,4-triazol-3-amineHCID 670058063-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropanoic acid

Product 1

HCID 592528953-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-N-(1-methyl-1H-1,2,4-triazol-3-yl)-3-phenylpropanamideYield 11%

Procedure

Example 137 was prepared from 3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-3-phenylpropanoic acid (50 mg, 0.14 mmol) and 1-methyl-1H-1,2,4-triazol-3-amine using General Coupling Method A to give 7 mg (11% yield). MS found: (M+H)+=441.5.

Workup

  1. customto give 7 mg (11% yield)

Sources & evidence

ORD record
ord-f9ad09484fc2457c842682e188c76e72
Source dataset
uspto-grants-2011_11
Patent number
US08067447B2

Reaction notes

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