HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,4-Thiadiazol-2-amine → (E)-3-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-2,2,5-trimethyl-N-(1,3,4-thiadiazol-2-yl)hex-3-enamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | (E)-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2,5-trimethylhex-3-enoic acid | HCID 67005634 | — |
| Product | (E)-3-(1-(4-Fluorophenyl)-1H-indazol-5-yl)-2,2,5-trimethyl-N-(1,3,4-thiadiazol-2-yl)hex-3-enamide | HCID 59252812 | 25% |
Reaction Steps
Example 139 was prepared from (E)-3-(1-(4-fluorophenyl)-1H-indazol-5-yl)-2,2,5-trimethylhex-3-enoic acid (105 mg, 0.29 mmol) and 1,3,4-thiadiazol-2-amine using General Coupling Method B to give 30 mg (25% yield). MS found: (M+H)+=450.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067447B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0ee8b9e1e3f849638c0b0a704e3166f8 |
| Source note | uspto-grants-2011_11 |