1,3,4-Thiadiazol-2-amine → 2-((1-(4-Fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)-N-(1,3,4-thiadiazol-2-yl)butanamide

HRID 563423Notes

Reaction equation

HRID 563423 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:18]([CH2:22][CH3:23])[C:19]([OH:21])=O)=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:4][CH:3]=1.[S:30]1[CH:34]=[N:33][N:32]=[C:31]1[NH2:35]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[C:16]3[C:11](=[CH:12][C:13]([CH:17]([C:24]4[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=4)[CH:18]([CH2:22][CH3:23])[C:19]([NH:35][C:31]4[S:30][CH:34]=[N:33][N:32]=4)=[O:21])=[CH:14][CH:15]=3)[CH:10]=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 199091,3,4-Thiadiazol-2-amineHCID 592511062-((1-(4-Fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)butanoic acid

Product 1

HCID 249374942-((1-(4-Fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)-N-(1,3,4-thiadiazol-2-yl)butanamideYield 35%

Procedure

Example 142 was prepared from 2-((1-(4-fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)butanoic acid (180 mg, 0.26 mmol) and 1,3,4-thiadiazol-2-amine using General Coupling Method B to give 75 mg (35% yield). MS found: (M+H)+=472.

Workup

  1. customto give 75 mg (35% yield)

Sources & evidence

ORD record
ord-fa793fdead964e7cbdbd7df6b61cfb9d
Source dataset
uspto-grants-2011_11
Patent number
US08067447B2

Reaction notes

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