HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,4-Thiadiazol-2-amine → 2-((1-(4-Fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)-N-(1,3,4-thiadiazol-2-yl)butanamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,4-Thiadiazol-2-amine | HCID 19909 | — |
| Reactant | 2-((1-(4-Fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)butanoic acid | HCID 59251106 | — |
| Product | 2-((1-(4-Fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)-N-(1,3,4-thiadiazol-2-yl)butanamide | HCID 24937494 | 35% |
Reaction Steps
Example 142 was prepared from 2-((1-(4-fluorophenyl)-1H-indazol-5-yl)(phenyl)methyl)butanoic acid (180 mg, 0.26 mmol) and 1,3,4-thiadiazol-2-amine using General Coupling Method B to give 75 mg (35% yield). MS found: (M+H)+=472.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08067447B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-fa793fdead964e7cbdbd7df6b61cfb9d |
| Source note | uspto-grants-2011_11 |