Ethanol → Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

HRID 563531Notes

Reaction equation

HRID 563531 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[CH:6][C:7]=1[OH:8].S(=O)(=O)(O)O.[CH3:18][CH2:19]O>>[CH2:18]([O:11][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([OH:8])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

Participants

4

Reactant 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 27696283-Bromo-4-hydroxyphenylacetic acid

Product 1

HCID 18620106Ethyl 2-(3-bromo-4-hydroxyphenyl)acetate

Procedure

(3-Bromo-4-hydroxy-phenyl)-acetic acid (5.6 mmol) in EtOH (20 mL) was treated with sulfuric acid (1 mL) and stirred at room temperature over the weekend. The mixture was concentrated to give the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-434516121a0b4996ae885f5f0b5347c6
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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