2-Bromo-5-nitrobenzoic acid → (2-Bromo-5-nitrophenyl)methanol

HRID 563537노트

반응식

HRID 563537 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](O)=[O:5].O1CCCC1.B>>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[CH2:4][OH:5]

참가 물질

3

반응물 2

HCID 2430252-Bromo-5-nitrobenzoic acidHCID 2723981Borane;tetrahydrofuran

생성물 1

HCID 18671373(2-Bromo-5-nitrophenyl)methanol

실험 절차

To 2-bromo-5-nitrobenzoic acid (5 g, 20 mmol) at 0° C. was added borane tetrahydrofuran complex (1 M in THF; 200 mL, 200 mmol), and the reaction was stirred at room temperature overnight. The mixture was quenched with 1N aqueous HCl to give the title compound.

후처리

  1. customThe mixture was quenched with 1N aqueous HCl

출처 및 근거

ORD 기록
ord-10610fa9968e4d3ba8c45c75675bc868
출처 데이터셋
uspto-grants-2011_11
특허 번호
US08067445B2

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