Lithium Hydroxide → [2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4'-(4-chloro-benzoylamino)-6-methoxy-biphenyl-3-yl]-acetic acid

HRID 563543Notes

Reaction equation

C([O:3][C:4](=[O:44])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([NH:20][C:21](=[O:29])[C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)=[CH:16][C:15]=2[CH2:30][N:31]([C:34]([O:36][CH2:37][C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[O:35])[CH2:32][CH3:33])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)C.[OH-].[Li+]>>[CH2:37]([O:36][C:34]([N:31]([CH2:30][C:15]1[CH:16]=[C:17]([NH:20][C:21](=[O:29])[C:22]2[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=2)[CH:18]=[CH:19][C:14]=1[C:8]1[C:9]([O:12][CH3:13])=[CH:10][CH:11]=[C:6]([CH2:5][C:4]([OH:44])=[O:3])[CH:7]=1)[CH2:32][CH3:33])=[O:35])[C:38]1[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58149045HCID 58149045, compound

Product 1

HCID 58148910[2'-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4'-(4-chloro-benzoylamino)-6-methoxy-biphenyl-3-yl]-acetic acid

Procedure

[2′-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4′-(4-chloro-benzoylamino)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester (0.2 mmol) was hydrolyzed with lithium hydroxide to give the title compound.

Sources & evidence

ORD record: ord-1b2121d3fb7a400cb8869ef8b1d8a2f9
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08067445B2

Reaction notes

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