Cyclopropanecarbonyl chloride → {2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-6,5'-dimethoxy-biphenyl-3-yl}-acetic acid methyl ester

HRID 563548Notes

Reaction equation

HRID 563548 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH2:21][NH:22][CH2:23][CH3:24])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1.[CH:26]1([C:29](Cl)=[O:30])[CH2:28][CH2:27]1>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:6]=[C:7]([C:13]2[CH:18]=[C:17]([O:19][CH3:20])[CH:16]=[CH:15][C:14]=2[CH2:21][N:22]([C:29]([CH:26]2[CH2:28][CH2:27]2)=[O:30])[CH2:23][CH3:24])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 77637Cyclopropanecarbonyl chlorideHCID 58148841(2'-Ethylaminomethyl-6,5'-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester

Product 1

HCID 58148988{2'-[(Cyclopropanecarbonyl-ethyl-amino)-methyl]-6,5'-dimethoxy-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (2′-ethylaminomethyl-6,5′-dimethoxy-biphenyl-3-yl)-acetic acid methyl ester and cyclopropanecarbonyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-62074991142b4e04b51c1814aaac2b10
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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