Hydrochloric Acid → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Hydrochloric Acid	HCID 313	—
Reactant	Methanol	HCID 887	—
Reactant	(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid	HCID 59644613	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester	HCID 58149337	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

To a solution of (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 4.8 mmol) in MeOH (10 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 80° C. for 1 hour. The mixture was concentrated and purified by silica gel chromatography to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08067445B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-f1cee4628dc2496591cc1b318d5feeea
Source note	uspto-grants-2011_11