Hydrochloric Acid → (3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

HRID 563550Notes

Reaction equation

HRID 563550 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH2:19][C:20]([OH:22])=[O:21])[CH:12]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[CH3:24]O>O1CCOCC1>[CH3:24][O:21][C:20](=[O:22])[CH2:19][C:11]1[CH:12]=[C:13]([C:15]([F:17])([F:18])[F:16])[CH:14]=[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:10]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 59644613(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid

Product 1

HCID 58149337(3-Benzyloxy-5-trifluoromethyl-phenyl)-acetic acid methyl ester

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of (3-benzyloxy-5-trifluoromethyl-phenyl)-acetic acid (1.5 g, 4.8 mmol) in MeOH (10 mL) was added 4N HCl in 1,4-dioxane (2 mL), and the reaction was stirred at 80° C. for 1 hour. The mixture was concentrated and purified by silica gel chromatography to give the title compound.

Workup

  1. concentrationThe mixture was concentrated
  2. custompurified by silica gel chromatography

Sources & evidence

ORD record
ord-f1cee4628dc2496591cc1b318d5feeea
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

Loading…