Water → HCID 57458797, compound

HRID 563552Notes

Reaction equation

HRID 563552 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:3]=1[CH2:4][NH:5][CH2:6][CH3:7].C(N(CC)CC)C.[CH3:23][N:24]=[C:25]=[O:26].O>C(Cl)Cl>[Br:1][C:2]1[CH:11]=[CH:10][C:9]([C:12]([F:13])([F:14])[F:15])=[CH:8][C:3]=1[CH2:4][N:5]([CH2:6][CH3:7])[C:25]([NH:24][CH3:23])=[O:26]

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 66603999(2-Bromo-5-trifluoromethyl-benzyl)-ethyl-amine

Product 1

HCID 57458797HCID 57458797, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To (2-bromo-5-trifluoromethyl-benzyl)-ethyl-amine (0.5 g, 1.8 mmol) in CH2Cl2 (5 mL) was added triethylamine (0.5 mL, 3.5 mmol), followed by methyl isocyanate (0.121 g, 2.2 mmol), and the reaction was stirred at room temperature under N2 for 30 minutes. The mixture was worked-up with CH2Cl2 and H2O, and the residue was purified by silica gel chromatography to give the title compound.

Workup

  1. customthe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-9d454c68700f4aefb5dfa76eaf3c4e33
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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