2-(3-Bromo-4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester → 2-(2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-2-methyl-propionic acid ethyl ester

HRID 563604Notes

Reaction equation

HRID 563604 reaction equation
[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[C:10](Br)[CH:9]=1)([CH3:7])[CH3:6])[CH3:2].CC1(C)C(C)(C)OB([C:26]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:27]=2[CH:28]=[O:29])O1>>[CH2:1]([O:3][C:4](=[O:17])[C:5]([C:8]1[CH:9]=[C:10]([C:26]2[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][C:27]=2[CH:28]=[O:29])[C:11]([O:14][CH3:15])=[CH:12][CH:13]=1)([CH3:7])[CH3:6])[CH3:2]

Participants

3

Reactant 2

HCID 574588052-(3-Bromo-4-methoxy-phenyl)-2-methyl-propionic acid ethyl esterHCID 866405342-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde

Product 1

HCID 866511152-(2'-Formyl-6-methoxy-4'-trifluoromethyl-biphenyl-3-yl)-2-methyl-propionic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: 2-(3-bromo-4-methoxy-phenyl)-2-methyl-propionic acid ethyl ester and 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzaldehyde.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-027682b6a859416185b21e7c20ce3550
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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