HCID 44159648, compound → HCID 54673387, compound

HRID 563610Notes

Reaction equation

HRID 563610 reaction equation
C(OC([N:11]([CH2:15][C:16]1[CH:21]=[C:20]([C:22]([F:25])([F:24])[F:23])[CH:19]=[CH:18][C:17]=1[C:26]1[C:31]([O:32][CH3:33])=[CH:30][CH:29]=[C:28]([CH2:34][C:35]([OH:37])=[O:36])[CH:27]=1)[CH:12]1[CH2:14][CH2:13]1)=O)C1C=CC=CC=1>[Pd].CO>[CH:12]1([NH:11][CH2:15][C:16]2[CH:21]=[C:20]([C:22]([F:24])([F:25])[F:23])[CH:19]=[CH:18][C:17]=2[C:26]2[C:31]([O:32][CH3:33])=[CH:30][CH:29]=[C:28]([CH2:34][C:35]([OH:37])=[O:36])[CH:27]=2)[CH2:14][CH2:13]1

Participants

4

Reactant 1

HCID 44159648HCID 44159648, compound

Product 1

HCID 54673387HCID 54673387, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

{2′-[(Benzyloxycarbonyl-cyclopropyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-acetic acid (0.054 g, 0.10 mmol) and 10% palladium on carbon (17.5 g) were combined in MeOH (2 mL) and stirred under a balloon of H2 at room temperature for 1 hour. The mixture was filtered and concentrated to give the title compound.

Workup

  1. filtrationThe mixture was filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-62c73db20b704abcb9f85daf3dd22c70
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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