Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | HCID 54673730 | HCID 54673730 | — |
| Catalyst | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86651118 | HCID 86651118 | — |
Reaction Steps
To 2-{2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-propionic acid (0.096 g, 0.21 mmol) and triethylamine (0.04 mL, 0.26 mmol) in CH2Cl2 (2 mL) at 0° C. was added oxalyl chloride (0.02 mL, 0.26 mmol), followed by DMF (2 drops), and the reaction was stirred at 0° C. for 1.5 hours. The mixture was concentrated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08067445B2 |
|---|
| Source dataset | uspto-grants-2011_11 |
|---|
| ORD ID | ord-817131bb74a14491929c8dcbf14b3cee |
|---|
| Source note | uspto-grants-2011_11 |
|---|
