Triethylamine → HCID 86651118, compound

HRID 563651Notes

Reaction equation

HRID 563651 reaction equation
[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=2[C:20]2[C:25]([O:26][CH3:27])=[CH:24][CH:23]=[C:22]([CH:28]([CH3:32])[C:29](O)=[O:30])[CH:21]=2)[CH2:7][CH3:8])=[O:5])[CH2:3][CH2:2]1.C(N(CC)CC)C.C(Cl)(=O)C([Cl:43])=O>C(Cl)Cl.CN(C=O)C>[CH:1]1([C:4]([N:6]([CH2:9][C:10]2[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=2[C:20]2[C:25]([O:26][CH3:27])=[CH:24][CH:23]=[C:22]([CH:28]([CH3:32])[C:29]([Cl:43])=[O:30])[CH:21]=2)[CH2:7][CH3:8])=[O:5])[CH2:3][CH2:2]1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 54673730HCID 54673730, compound

Product 1

HCID 86651118HCID 86651118, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To 2-{2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-6-methoxy-4′-trifluoromethyl-biphenyl-3-yl}-propionic acid (0.096 g, 0.21 mmol) and triethylamine (0.04 mL, 0.26 mmol) in CH2Cl2 (2 mL) at 0° C. was added oxalyl chloride (0.02 mL, 0.26 mmol), followed by DMF (2 drops), and the reaction was stirred at 0° C. for 1.5 hours. The mixture was concentrated to give the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-817131bb74a14491929c8dcbf14b3cee
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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