3-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4-bromo-benzoic acid → 2-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-5'-ethoxycarbonylmethyl-2'-methoxy-biphenyl-4-carboxylic acid

HRID 563677Notes

Reaction equation

HRID 563677 reaction equation
[CH2:1]([O:8][C:9]([N:11]([CH2:14][C:15]1[CH:16]=[C:17]([CH:21]=[CH:22][C:23]=1Br)[C:18]([OH:20])=[O:19])[CH2:12][CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:25]([O:27][C:28](=[O:47])[CH2:29][C:30]1[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32](B2OC(C)(C)C(C)(C)O2)[CH:31]=1)[CH3:26]>>[CH2:1]([O:8][C:9]([N:11]([CH2:14][C:15]1[CH:16]=[C:17]([C:18]([OH:20])=[O:19])[CH:21]=[CH:22][C:23]=1[C:32]1[CH:31]=[C:30]([CH2:29][C:28]([O:27][CH2:25][CH3:26])=[O:47])[CH:35]=[CH:34][C:33]=1[O:36][CH3:37])[CH2:12][CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 574198643-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-4-bromo-benzoic acidHCID 58120060[4-Methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester

Product 1

HCID 546743292-[(Benzyloxycarbonyl-ethyl-amino)-methyl]-5'-ethoxycarbonylmethyl-2'-methoxy-biphenyl-4-carboxylic acid

Procedure

Prepared according to the procedure described in Example 1, Step 4, using the following starting materials: 3-[(benzyloxycarbonyl-ethyl-amino)-methyl]-4-bromo-benzoic acid and [4-methoxy-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-acetic acid ethyl ester. M+H is 506.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-eee2d4fd3ba3495cbf08131f2075c95f
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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