Cyclopropanecarbonyl chloride → HCID 58149321, compound

HRID 563723Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:31])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:25]=[CH:24][C:23]([F:26])=[CH:22][N:21]=3)=[CH:16][C:15]=2[CH2:27][NH:28][CH2:29][CH3:30])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[CH:32]1([C:35](Cl)=[O:36])[CH2:34][CH2:33]1>>[CH2:1]([O:3][C:4](=[O:31])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[N:21]=[CH:22][C:23]([F:26])=[CH:24][N:25]=3)=[CH:16][C:15]=2[CH2:27][N:28]([C:35]([CH:32]2[CH2:34][CH2:33]2)=[O:36])[CH2:29][CH3:30])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 58149254HCID 58149254, compound

Product 1

HCID 58149321HCID 58149321, compound

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: [2′-ethylaminomethyl-4′-(5-fluoro-pyrimidin-2-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester and cyclopropanecarbonyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-ad72a78a094b4595a03861166f0f463a
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08067445B2

Reaction notes

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