反应详情

温度

90 °C

To a solution of (3-bromo-5-chloro-phenyl)-acetic acid (0.400 g, 1.60 mmol) in MeOH (15 mL) was added 4N aqueous HCl (2 mL), and the reaction was stirred at 90° C. for 2 hours. The mixture was concentrated and purified by silica gel chromatography (0-5% EtOAc in hexanes) to give the title compound.

1. concentrationThe mixture was concentrated
2. custompurified by silica gel chromatography (0-5% EtOAc in hexanes)