Cyclopropanecarbonyl chloride → {5-Chloro-2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-5'-methoxy-biphenyl-3-yl}-acetic acid methyl ester

HRID 563752Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH2:20][NH:21][CH2:22][CH3:23])[CH:8]=[C:9]([Cl:11])[CH:10]=1.[CH:25]1([C:28](Cl)=[O:29])[CH2:27][CH2:26]1>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:6]=[C:7]([C:12]2[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:13]=2[CH2:20][N:21]([C:28]([CH:25]2[CH2:27][CH2:26]2)=[O:29])[CH2:22][CH3:23])[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 58148889HCID 58148889, compound

Product 1

HCID 58149184{5-Chloro-2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-5'-methoxy-biphenyl-3-yl}-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: (5-chloro-2′-ethylaminomethyl-5′-methoxy-biphenyl-3-yl)-acetic acid methyl ester and cyclopropanecarbonyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-6d1e9ecfe93842f3add12a36eebe2f95
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08067445B2

Reaction notes

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