p-Chlorophenoxyacetyl chloride → [2'-({[2-(4-Chloro-phenoxy)-acetyl]-ethyl-amino}-methyl)-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

HRID 563759Notes

Reaction equation

HRID 563759 reaction equation
[CH2:1]([O:3][C:4](=[O:33])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][C:23]([O:26][CH2:27][CH3:28])=[CH:24][CH:25]=3)=[CH:16][C:15]=2[CH2:29][NH:30][CH2:31][CH3:32])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2].[Cl:34][C:35]1[CH:45]=[CH:44][C:38]([O:39][CH2:40][C:41](Cl)=[O:42])=[CH:37][CH:36]=1>>[CH2:1]([O:3][C:4](=[O:33])[CH2:5][C:6]1[CH:7]=[C:8]([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:21]=[N:22][C:23]([O:26][CH2:27][CH3:28])=[CH:24][CH:25]=3)=[CH:16][C:15]=2[CH2:29][N:30]([C:41](=[O:42])[CH2:40][O:39][C:38]2[CH:44]=[CH:45][C:35]([Cl:34])=[CH:36][CH:37]=2)[CH2:31][CH3:32])[C:9]([O:12][CH3:13])=[CH:10][CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 77771p-Chlorophenoxyacetyl chlorideHCID 58148820[4'-(6-Ethoxy-pyridin-3-yl)-2'-ethylaminomethyl-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

Product 1

HCID 58149310[2'-({[2-(4-Chloro-phenoxy)-acetyl]-ethyl-amino}-methyl)-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester

Procedure

Prepared according to the procedure described in Example 1, Step 6, using the following starting materials: [4′-(6-ethoxy-pyridin-3-yl)-2′-ethylaminomethyl-6-methoxy-biphenyl-3-yl]-acetic acid ethyl ester and 4-chlorophenoxyacetyl chloride.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-c54bce9e6b294934be368d6b86dddc1f
Source dataset
uspto-grants-2011_11
Patent number
US08067445B2

Reaction notes

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